6P1W
Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-nt gapped substrate containing undamaged template dG and bound incoming CMPCPP
Summary for 6P1W
Entry DOI | 10.2210/pdb6p1w/pdb |
Descriptor | DNA-directed DNA/RNA polymerase mu, 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*GP*CP*GP*TP*AP*CP*G)-3'), ... (11 entities in total) |
Functional Keywords | family x polymerase, nhej, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 45978.59 |
Authors | Kaminski, A.M.,Pedersen, L.C.,Bebenek, K.,Chiruvella, K.K.,Ramsden, D.A.,Kunkel, T.A. (deposition date: 2019-05-20, release date: 2019-09-04, Last modification date: 2023-10-11) |
Primary citation | Kaminski, A.M.,Chiruvella, K.K.,Ramsden, D.A.,Kunkel, T.A.,Bebenek, K.,Pedersen, L.C. Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47:9410-9422, 2019 Cited by PubMed: 31435651DOI: 10.1093/nar/gkz680 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.751 Å) |
Structure validation
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