6P0P
Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-2-(3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-[1,1'-biphenyl]-3-yl)-2-hydroxy-2H-1,3,2-benzodioxaborol-2-uide
Summary for 6P0P
Entry DOI | 10.2210/pdb6p0p/pdb |
Descriptor | Tryptase alpha/beta-1, (3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1,1'-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappaO)phenyl]methanonato(2-)hydroxyborate(1-), SULFATE ION, ... (6 entities in total) |
Functional Keywords | tryptase, bivalent inhibitor, protease inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 62633.68 |
Authors | Giardina, S.F.,Pingle, M.R.,Werner, D.S.,Feinberg, P.B.,Foreman, K.W.,Bergstrom, D.E.,Arnold, L.D.,Barany, F. (deposition date: 2019-05-17, release date: 2020-03-25, Last modification date: 2023-10-11) |
Primary citation | Giardina, S.F.,Werner, D.S.,Pingle, M.,Feinberg, P.B.,Foreman, K.W.,Bergstrom, D.E.,Arnold, L.D.,Barany, F. Novel, Self-Assembling Dimeric Inhibitors of Human beta Tryptase. J.Med.Chem., 63:3004-3027, 2020 Cited by PubMed: 32057241DOI: 10.1021/acs.jmedchem.9b01689 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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