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6P0P

Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-2-(3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-[1,1'-biphenyl]-3-yl)-2-hydroxy-2H-1,3,2-benzodioxaborol-2-uide

Summary for 6P0P
Entry DOI10.2210/pdb6p0p/pdb
DescriptorTryptase alpha/beta-1, (3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1,1'-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappaO)phenyl]methanonato(2-)hydroxyborate(1-), SULFATE ION, ... (6 entities in total)
Functional Keywordstryptase, bivalent inhibitor, protease inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight62633.68
Authors
Giardina, S.F.,Pingle, M.R.,Werner, D.S.,Feinberg, P.B.,Foreman, K.W.,Bergstrom, D.E.,Arnold, L.D.,Barany, F. (deposition date: 2019-05-17, release date: 2020-03-25, Last modification date: 2023-10-11)
Primary citationGiardina, S.F.,Werner, D.S.,Pingle, M.,Feinberg, P.B.,Foreman, K.W.,Bergstrom, D.E.,Arnold, L.D.,Barany, F.
Novel, Self-Assembling Dimeric Inhibitors of Human beta Tryptase.
J.Med.Chem., 63:3004-3027, 2020
Cited by
PubMed: 32057241
DOI: 10.1021/acs.jmedchem.9b01689
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

223166

건을2024-07-31부터공개중

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