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6OXW

HIV-1 Protease NL4-3 WT in Complex with LR-100

Summary for 6OXW
Entry DOI10.2210/pdb6oxw/pdb
DescriptorProtease NL4-3, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[(2-ethylbutyl)({4-[(1R)-1-hydroxyethyl]phenyl}sulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate (3 entities in total)
Functional Keywordshiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22268.42
Authors
Lockbaum, G.J.,Rusere, L.N.,Lee, S.K.,Henes, M.,Kosovrasti, K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,KurtYilmaz, N.,Schiffer, C.A.,Ali, A. (deposition date: 2019-05-14, release date: 2019-08-21, Last modification date: 2023-10-11)
Primary citationRusere, L.N.,Lockbaum, G.J.,Lee, S.K.,Henes, M.,Kosovrasti, K.,Spielvogel, E.,Nalivaika, E.A.,Swanstrom, R.,Yilmaz, N.K.,Schiffer, C.A.,Ali, A.
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
J.Med.Chem., 62:8062-8079, 2019
Cited by
PubMed: 31386368
DOI: 10.1021/acs.jmedchem.9b00838
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.982 Å)
Structure validation

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