6OWC

Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545.

Summary for 6OWC

DescriptorEstrogen receptor, (2Z)-N,N-dimethyl-4-{[2-({5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-2H-indazol-5-yl)-2-phenylbut-1-en-1-yl]pyridin-2-yl}oxy)ethyl]amino}but-2-enamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsnuclear hormone receptor, h3b-6545, inhibitor, serm, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight59878.26
Authors
Larsen, N.A. (deposition date: 2019-05-09, release date: 2019-06-19)
Primary citation
Furman, C.
Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545.
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2335 0.2% 4.7% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution