6OWC
Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 258 | 29340.5 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A, B | (2Z)-N,N-dimethyl-4-{[2-({5-[(1Z)-4,4,4-trifluoro-1-(3-fluoro-2H-indazol-5-yl)-2-phenylbut-1-en-1-yl]pyridin-2-yl}oxy)ethyl]amino}but-2-enamide | non-polymer | 567.6 | 2 | Chemie (ND1) | |||
| 3 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 297 | - | expression tag |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58681.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1197.2 | |
| All* | Total formula weight | 59878.3 |
