6OWC
Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ND1 A 601 |
| Chain | Residue |
| A | MET343 |
| A | LEU391 |
| A | PHE404 |
| A | ILE424 |
| A | LEU428 |
| A | GLY521 |
| A | TYR526 |
| A | LYS529 |
| A | CYS530 |
| A | LEU346 |
| A | THR347 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | TRP383 |
| A | LEU387 |
| A | MET388 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| A | ARG434 |
| A | GLN506 |
| A | LEU509 |
| A | HOH735 |
| B | HIS476 |
| B | LEU479 |
| B | ASP480 |
| B | HOH756 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide ND1 B 601 and CYS B 530 |
| Chain | Residue |
| B | LEU346 |
| B | THR347 |
| B | ALA350 |
| B | GLU353 |
| B | LEU387 |
| B | MET388 |
| B | LEU391 |
| B | ARG394 |
| B | PHE404 |
| B | MET421 |
| B | ILE424 |
| B | PHE425 |
| B | LEU428 |
| B | GLY521 |
| B | LEU525 |
| B | MET528 |
| B | LYS529 |
| B | LYS531 |
| B | HOH730 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 |
