6OTG

HIV-1 protease triple mutants V32I, I47V, V82I with GRL-011-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, sulfonamide isostere derivate)

Summary for 6OTG

Entry DOI	10.2210/pdb6otg/pdb
Related	2IEN 3S54 5BRY
Descriptor	Protease, FORMIC ACID, (3R,3aS,4R,6aR)-4-(methylamino)hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, ... (5 entities in total)
Functional Keywords	hiv-1 protease; antiviral inhibitors; drug resistance; x-ray crystallography, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22377.32
Authors	Wang, Y.-F.,Pawar, S.,Weber, I.T. (deposition date: 2019-05-03, release date: 2019-05-29, Last modification date: 2023-10-11)
Primary citation	Pawar, S.,Wang, Y.F.,Wong-Sam, A.,Agniswamy, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I. Biochem.Biophys.Res.Commun., 514:974-978, 2019 Cited by PubMed: 31092330 DOI: 10.1016/j.bbrc.2019.05.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation