6OT0
Structure of human Smoothened-Gi complex
Summary for 6OT0
Entry DOI | 10.2210/pdb6ot0/pdb |
EMDB information | 20190 |
Descriptor | Smoothened homolog, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | gpcr, complex, hedgehog signaling, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 198577.19 |
Authors | |
Primary citation | Qi, X.,Liu, H.,Thompson, B.,McDonald, J.,Zhang, C.,Li, X. Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Nature, 571:279-283, 2019 Cited by PubMed: 31168089DOI: 10.1038/s41586-019-1286-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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