6OSV

Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2

Summary for 6OSV

Entry DOI	10.2210/pdb6osv/pdb
Descriptor	Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2, Antibody heavy chain variable region, ... (4 entities in total)
Functional Keywords	single chain fv, scfv, antibody, ror2, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system, immune sytem-transferase complex, immune sytem/transferase
Biological source	Oryctolagus cuniculus More
Total number of polymer chains	3
Total formula weight	36110.97
Authors	Park, H.,Rader, C. (deposition date: 2019-05-02, release date: 2020-04-01, Last modification date: 2020-05-13)
Primary citation	Goydel, R.S.,Weber, J.,Peng, H.,Qi, J.,Soden, J.,Freeth, J.,Park, H.,Rader, C. Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications. J.Biol.Chem., 295:5995-6006, 2020 Cited by PubMed: 32193207 DOI: 10.1074/jbc.RA120.012791 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation