6OSV

Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (L)	Antibody light chain variable region	polymer	111	11818.1	1		Oryctolagus cuniculus
2	B (K)	Tyrosine-protein kinase transmembrane receptor ROR2	polymer	98	10932.1	1	UniProt (Q01974) Pfam (PF00051)	Homo sapiens (Human)	Neurotrophic tyrosine kinase,receptor-related 2
3	C (H)	Antibody heavy chain variable region	polymer	126	13360.8	1		Oryctolagus cuniculus
4	D, E, F (L, K, H)	water	water		18.0	338	Chemie (HOH)

Sequence modifications

K: 314 - 394 (UniProt: Q01974)

PDB	External Database	Details
Met 297	-	initiating methionine
Gly 298	-	expression tag
Ser 299	-	expression tag
His 300	-	expression tag
His 301	-	expression tag
His 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
Ser 306	-	expression tag
Val 307	-	expression tag
Pro 308	-	expression tag
Arg 309	-	expression tag
Gly 310	-	expression tag
Ser 311	-	expression tag
His 312	-	expression tag
Met 313	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	36111.0
All*	Total formula weight	36111.0

*Water molecules are not included.