6OQX

Human Liver Receptor Homolog-1 bound to the agonist 5N and a fragment of the Tif2 coregulator

6OQX の概要

• エントリーDOI: 10.2210/pdb6oqx/pdb
• 分子名称: Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, (8beta,11alpha,12alpha)-8-(1-phenylethenyl)-1,6:7,14-dicycloprosta-1,3,5,7(14)-tetraen-11-yl sulfamate, ... (4 entities in total)
• 機能のキーワード: nuclear hormone receptor, agonist, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30606.38

構造登録者

Mays, S.G.,Ortlund, E.A. (登録日: 2019-04-29, 公開日: 2019-08-28, 最終更新日: 2023-10-11)

• 主引用文献: Mays, S.G.,Flynn, A.R.,Cornelison, J.L.,Okafor, C.D.,Wang, H.,Wang, G.,Huang, X.,Donaldson, H.N.,Millings, E.J.,Polavarapu, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A.; Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.; J.Med.Chem., 62:11022-11034, 2019; PubMed: 31419141; DOI: 10.1021/acs.jmedchem.9b00753

実験手法

X-RAY DIFFRACTION (2.004 Å)