6OQC
Crystal structure of Mcl1 with inhibitor 9
Summary for 6OQC
Entry DOI | 10.2210/pdb6oqc/pdb |
Related | 6O6F 6O6G 6OQB |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, (4S,7aR,9aR,10S,11E,15R)-6'-chloro-10-hydroxy-15-methyl-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione (3 entities in total) |
Functional Keywords | mcl1, apoptosis, protein-protein, inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 37015.00 |
Authors | Huang, X. (deposition date: 2019-04-26, release date: 2019-05-15, Last modification date: 2024-03-13) |
Primary citation | Huang, X. AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. CANCER DISCOV, 8:1582-1597, 2018 Cited by PubMed: 30254093DOI: 10.1158/2159-8290.CD-18-0387 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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