6OLX
Hsp90-alpha S52A bound to PU-11-trans
Summary for 6OLX
Entry DOI | 10.2210/pdb6olx/pdb |
Related | 6N8W 6N8X 6N8Y |
Descriptor | Heat shock protein HSP 90-alpha, 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine (3 entities in total) |
Functional Keywords | hsp90, chaperone, cytosol, cancer, inhibitor, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29126.56 |
Authors | Gewirth, D.T.,Huck, J.D. (deposition date: 2019-04-17, release date: 2019-07-03, Last modification date: 2024-03-06) |
Primary citation | Huck, J.D.,Que, N.L.S.,Sharma, S.,Taldone, T.,Chiosis, G.,Gewirth, D.T. Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins, 87:869-877, 2019 Cited by PubMed: 31141217DOI: 10.1002/prot.25750 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43760580022 Å) |
Structure validation
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