6OL2

Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening

Summary for 6OL2

• Entry DOI: 10.2210/pdb6ol2/pdb
• Descriptor: Serine/threonine-protein kinase WNK1, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 1
• Total formula weight: 34505.28

Authors

Chlebowicz, J.,Akella, R.,Sekulski, K.,Humphreys, J.M.,Durbacz, M.Z.,He, H.,Rodan, A.,Posner, B.,Goldsmith, E.J. (deposition date: 2019-04-15, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Chlebowicz, J.,Akella, R.,Sekulski, K.,Humphreys, J.M.,Durbacz, M.Z.,He, H.,Rodan, A.,Posner, B.,Goldsmith, E.J.; Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)