6OL2
Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase WNK1 | polymer | 290 | 33481.5 | 1 | UniProt (Q9JIH7) Pfam (PF00069) In PDB | Rattus norvegicus (Rat) | Protein kinase lysine-deficient 1, Protein kinase with no lysine 1 |
| 2 | A | N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide | non-polymer | 478.3 | 1 | Chemie (MU7) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A: 194 - 483 (UniProt: Q9JIH7)
| PDB | External Database | Details |
|---|---|---|
| Ala 382 | Ser 382 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33481.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1023.8 | |
| All* | Total formula weight | 34505.3 |
