6OHP
Structure of compound 1 (halopemide) bound human Phospholipase D2 catalytic domain
Summary for 6OHP
Entry DOI | 10.2210/pdb6ohp/pdb |
Descriptor | Phospholipase D2, N-{2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl}-4-fluorobenzamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, hydrolase, hkd motif, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 294131.13 |
Authors | Metrick, C.M.,Chodaparambil, J.V. (deposition date: 2019-04-06, release date: 2020-02-19, Last modification date: 2023-11-15) |
Primary citation | Metrick, C.M.,Peterson, E.A.,Santoro, J.C.,Enyedy, I.J.,Murugan, P.,Chen, T.,Michelsen, K.,Cullivan, M.,Spilker, K.A.,Kumar, P.R.,May-Dracka, T.L.,Chodaparambil, J.V. Human PLD structures enable drug design and characterization of isoenzyme selectivity. Nat.Chem.Biol., 16:391-399, 2020 Cited by PubMed: 32042197DOI: 10.1038/s41589-019-0458-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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