6OHP
Structure of compound 1 (halopemide) bound human Phospholipase D2 catalytic domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004630 | molecular_function | phospholipase D activity |
| A | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| A | 0035556 | biological_process | intracellular signal transduction |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004630 | molecular_function | phospholipase D activity |
| B | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| B | 0035556 | biological_process | intracellular signal transduction |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004630 | molecular_function | phospholipase D activity |
| C | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| C | 0035556 | biological_process | intracellular signal transduction |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004630 | molecular_function | phospholipase D activity |
| D | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| D | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue MJV A 1001 |
| Chain | Residue |
| A | TRP364 |
| A | ASP518 |
| A | TRP519 |
| A | TRP540 |
| A | GLN642 |
| A | PHE643 |
| A | GLY686 |
| A | ASN773 |
| A | ARG777 |
| A | ASP784 |
| A | TRP365 |
| A | LEU409 |
| A | GLY410 |
| A | ILE411 |
| A | ALA440 |
| A | HIS442 |
| A | ARG464 |
| A | LEU514 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1002 |
| Chain | Residue |
| A | GLN844 |
| A | GLN847 |
| A | ASP848 |
| A | GLU851 |
| B | GLU632 |
| B | LYS667 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1003 |
| Chain | Residue |
| A | GLN642 |
| A | PHE643 |
| A | PHE644 |
| A | LEU681 |
| A | PRO682 |
| A | THR706 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1004 |
| Chain | Residue |
| A | LEU683 |
| A | ARG739 |
| A | ALA854 |
| A | TYR857 |
| A | CYS863 |
| A | HIS905 |
| A | HOH1117 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1005 |
| Chain | Residue |
| A | PHE504 |
| A | LEU507 |
| A | GLY508 |
| A | PHE526 |
| A | ASP528 |
| A | ARG532 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue MJV B 1001 |
| Chain | Residue |
| B | TRP364 |
| B | TRP365 |
| B | LEU409 |
| B | GLY410 |
| B | LEU438 |
| B | ALA440 |
| B | HIS442 |
| B | ARG464 |
| B | LEU514 |
| B | TRP519 |
| B | GLN642 |
| B | PHE643 |
| B | GLY686 |
| B | ASN773 |
| B | ARG777 |
| B | ASP784 |
| D | MET926 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 1002 |
| Chain | Residue |
| B | TRP439 |
| B | ASP776 |
| B | ARG777 |
| B | ARG783 |
| B | GLU930 |
| B | THR933 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 1003 |
| Chain | Residue |
| B | ALA327 |
| B | PRO328 |
| B | PRO329 |
| B | ARG330 |
| B | PRO551 |
| B | ASP554 |
| B | VAL604 |
| B | GLN605 |
| B | VAL606 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 1004 |
| Chain | Residue |
| B | ARG471 |
| B | LEU472 |
| B | THR473 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 1005 |
| Chain | Residue |
| B | TYR326 |
| B | ASP554 |
| B | ARG557 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue MJV C 1001 |
| Chain | Residue |
| A | MET926 |
| C | TRP364 |
| C | TRP365 |
| C | LEU409 |
| C | GLY410 |
| C | ILE411 |
| C | ALA440 |
| C | HIS442 |
| C | ARG464 |
| C | LEU514 |
| C | ASP518 |
| C | TRP519 |
| C | TRP540 |
| C | GLN642 |
| C | GLY686 |
| C | ASN773 |
| C | ARG777 |
| C | ASP784 |
| site_id | AD3 |
| Number of Residues | 16 |
| Details | binding site for residue MJV D 1001 |
| Chain | Residue |
| B | MET926 |
| D | TRP364 |
| D | TRP365 |
| D | LEU409 |
| D | GLY410 |
| D | ILE411 |
| D | LEU438 |
| D | ALA440 |
| D | HIS442 |
| D | ARG464 |
| D | TRP519 |
| D | GLN642 |
| D | GLY686 |
| D | ASN773 |
| D | ARG777 |
| D | ASP784 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 108 |
| Details | Domain: {"description":"PLD phosphodiesterase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 108 |
| Details | Domain: {"description":"PLD phosphodiesterase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
