6OHP
Structure of compound 1 (halopemide) bound human Phospholipase D2 catalytic domain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004630 | molecular_function | phospholipase D activity |
A | 0006654 | biological_process | phosphatidic acid biosynthetic process |
A | 0035556 | biological_process | intracellular signal transduction |
B | 0003824 | molecular_function | catalytic activity |
B | 0004630 | molecular_function | phospholipase D activity |
B | 0006654 | biological_process | phosphatidic acid biosynthetic process |
B | 0035556 | biological_process | intracellular signal transduction |
C | 0003824 | molecular_function | catalytic activity |
C | 0004630 | molecular_function | phospholipase D activity |
C | 0006654 | biological_process | phosphatidic acid biosynthetic process |
C | 0035556 | biological_process | intracellular signal transduction |
D | 0003824 | molecular_function | catalytic activity |
D | 0004630 | molecular_function | phospholipase D activity |
D | 0006654 | biological_process | phosphatidic acid biosynthetic process |
D | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue MJV A 1001 |
Chain | Residue |
A | TRP364 |
A | ASP518 |
A | TRP519 |
A | TRP540 |
A | GLN642 |
A | PHE643 |
A | GLY686 |
A | ASN773 |
A | ARG777 |
A | ASP784 |
A | TRP365 |
A | LEU409 |
A | GLY410 |
A | ILE411 |
A | ALA440 |
A | HIS442 |
A | ARG464 |
A | LEU514 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 1002 |
Chain | Residue |
A | GLN844 |
A | GLN847 |
A | ASP848 |
A | GLU851 |
B | GLU632 |
B | LYS667 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue GOL A 1003 |
Chain | Residue |
A | GLN642 |
A | PHE643 |
A | PHE644 |
A | LEU681 |
A | PRO682 |
A | THR706 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL A 1004 |
Chain | Residue |
A | LEU683 |
A | ARG739 |
A | ALA854 |
A | TYR857 |
A | CYS863 |
A | HIS905 |
A | HOH1117 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 1005 |
Chain | Residue |
A | PHE504 |
A | LEU507 |
A | GLY508 |
A | PHE526 |
A | ASP528 |
A | ARG532 |
site_id | AC6 |
Number of Residues | 17 |
Details | binding site for residue MJV B 1001 |
Chain | Residue |
B | TRP364 |
B | TRP365 |
B | LEU409 |
B | GLY410 |
B | LEU438 |
B | ALA440 |
B | HIS442 |
B | ARG464 |
B | LEU514 |
B | TRP519 |
B | GLN642 |
B | PHE643 |
B | GLY686 |
B | ASN773 |
B | ARG777 |
B | ASP784 |
D | MET926 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue SO4 B 1002 |
Chain | Residue |
B | TRP439 |
B | ASP776 |
B | ARG777 |
B | ARG783 |
B | GLU930 |
B | THR933 |
site_id | AC8 |
Number of Residues | 9 |
Details | binding site for residue SO4 B 1003 |
Chain | Residue |
B | ALA327 |
B | PRO328 |
B | PRO329 |
B | ARG330 |
B | PRO551 |
B | ASP554 |
B | VAL604 |
B | GLN605 |
B | VAL606 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 1004 |
Chain | Residue |
B | ARG471 |
B | LEU472 |
B | THR473 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 1005 |
Chain | Residue |
B | TYR326 |
B | ASP554 |
B | ARG557 |
site_id | AD2 |
Number of Residues | 18 |
Details | binding site for residue MJV C 1001 |
Chain | Residue |
A | MET926 |
C | TRP364 |
C | TRP365 |
C | LEU409 |
C | GLY410 |
C | ILE411 |
C | ALA440 |
C | HIS442 |
C | ARG464 |
C | LEU514 |
C | ASP518 |
C | TRP519 |
C | TRP540 |
C | GLN642 |
C | GLY686 |
C | ASN773 |
C | ARG777 |
C | ASP784 |
site_id | AD3 |
Number of Residues | 16 |
Details | binding site for residue MJV D 1001 |
Chain | Residue |
B | MET926 |
D | TRP364 |
D | TRP365 |
D | LEU409 |
D | GLY410 |
D | ILE411 |
D | LEU438 |
D | ALA440 |
D | HIS442 |
D | ARG464 |
D | TRP519 |
D | GLN642 |
D | GLY686 |
D | ASN773 |
D | ARG777 |
D | ASP784 |