6ODE

Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor B6

Summary for 6ODE

• Entry DOI: 10.2210/pdb6ode/pdb
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, N-{(2S)-1-({(1S)-1-[5-(2-fluorophenyl)-1H-imidazol-2-yl]ethyl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide, ... (4 entities in total)
• Functional Keywords: mycobacterium tuberculosis, proteasome inhibitor, phenylimidazole, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 28
• Total formula weight: 713663.45

Authors

Hsu, H.C.,Li, H. (deposition date: 2019-03-26, release date: 2019-10-09, Last modification date: 2023-10-11)

• Primary citation: Zhan, W.,Hsu, H.C.,Morgan, T.,Ouellette, T.,Burns-Huang, K.,Hara, R.,Wright, A.G.,Imaeda, T.,Okamoto, R.,Sato, K.,Michino, M.,Ramjee, M.,Aso, K.,Meinke, P.T.,Foley, M.,Nathan, C.F.,Li, H.,Lin, G.; Selective Phenylimidazole-Based Inhibitors of theMycobacterium tuberculosisProteasome.; J.Med.Chem., 62:9246-9253, 2019; PubMed: 31560200; DOI: 10.1021/acs.jmedchem.9b01187

Experimental method

X-RAY DIFFRACTION (2.9 Å)