6OCO

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 6

Summary for 6OCO

• Entry DOI: 10.2210/pdb6oco/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 4-[(1S,4S)-5-(3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-(pyridin-3-yl)pyrimidine-5-carbonitrile, ... (4 entities in total)
• Functional Keywords: pi3kdelta kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 137569.67

Authors

Lesburg, C.A.,Augustin, M.A. (deposition date: 2019-03-25, release date: 2019-12-11, Last modification date: 2024-03-13)

• Primary citation: Zhou, H.,McGowan, M.A.,Lipford, K.,Christopher, M.,Fradera, X.,Witter, D.,Lesburg, C.A.,Li, C.,Methot, J.L.,Lampe, J.,Achab, A.,Shaffer, L.,Goldenblatt, P.,Shah, S.,Bass, A.,Schroeder, G.,Chen, D.,Zeng, H.,Augustin, M.A.,Katz, J.D.; Discovery and optimization of heteroaryl piperazines as potent and selective PI3K delta inhibitors.; Bioorg.Med.Chem.Lett., 30:126715-126715, 2020; PubMed: 31757666; DOI: 10.1016/j.bmcl.2019.126715

Experimental method

X-RAY DIFFRACTION (2.58 Å)