6O8C

Crystal structure of STING CTT in complex with TBK1

Summary for 6O8C

• Entry DOI: 10.2210/pdb6o8c/pdb
• Descriptor: Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide (3 entities in total)
• Functional Keywords: adaptor, kinase, complex, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 162328.60

Authors

Li, P.,Zhao, B.,Du, F. (deposition date: 2019-03-09, release date: 2019-05-22, Last modification date: 2023-10-11)

• Primary citation: Zhao, B.,Du, F.,Xu, P.,Shu, C.,Sankaran, B.,Bell, S.L.,Liu, M.,Lei, Y.,Gao, X.,Fu, X.,Zhu, F.,Liu, Y.,Laganowsky, A.,Zheng, X.,Ji, J.Y.,West, A.P.,Watson, R.O.,Li, P.; A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.; Nature, 569:718-722, 2019; PubMed: 31118511; DOI: 10.1038/s41586-019-1228-x

Experimental method

X-RAY DIFFRACTION (3.17 Å)