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6O8C

Crystal structure of STING CTT in complex with TBK1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002218biological_processactivation of innate immune response
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003676molecular_functionnucleic acid binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006468biological_processprotein phosphorylation
A0010468biological_processregulation of gene expression
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016239biological_processpositive regulation of macroautophagy
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019903molecular_functionprotein phosphatase binding
A0032479biological_processregulation of type I interferon production
A0032481biological_processpositive regulation of type I interferon production
A0032727biological_processpositive regulation of interferon-alpha production
A0032728biological_processpositive regulation of interferon-beta production
A0034142biological_processtoll-like receptor 4 signaling pathway
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043231cellular_componentintracellular membrane-bounded organelle
A0044565biological_processdendritic cell proliferation
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050830biological_processdefense response to Gram-positive bacterium
A0051219molecular_functionphosphoprotein binding
A0051607biological_processdefense response to virus
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0106310molecular_functionprotein serine kinase activity
A0140374biological_processantiviral innate immune response
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904417biological_processpositive regulation of xenophagy
B0002218biological_processactivation of innate immune response
B0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
B0003676molecular_functionnucleic acid binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006468biological_processprotein phosphorylation
B0010468biological_processregulation of gene expression
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0016239biological_processpositive regulation of macroautophagy
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019903molecular_functionprotein phosphatase binding
B0032479biological_processregulation of type I interferon production
B0032481biological_processpositive regulation of type I interferon production
B0032727biological_processpositive regulation of interferon-alpha production
B0032728biological_processpositive regulation of interferon-beta production
B0034142biological_processtoll-like receptor 4 signaling pathway
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043231cellular_componentintracellular membrane-bounded organelle
B0044565biological_processdendritic cell proliferation
B0045087biological_processinnate immune response
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050830biological_processdefense response to Gram-positive bacterium
B0051219molecular_functionphosphoprotein binding
B0051607biological_processdefense response to virus
B0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
B0106310molecular_functionprotein serine kinase activity
B0140374biological_processantiviral innate immune response
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
B1904417biological_processpositive regulation of xenophagy
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue BX7 A 701
ChainResidue
ALEU15
AGLU87
APHE88
ACYS89
AGLY92
ASER93
ATHR96
AGLY139
AMET142
ATHR156
AGLY16
AGLN17
AGLY18
AALA21
AVAL23
AALA36
ALYS38
AMET86

site_idAC2
Number of Residues17
Detailsbinding site for residue BX7 B 701
ChainResidue
BLEU15
BGLY18
BVAL23
BALA36
BMET86
BGLU87
BPHE88
BCYS89
BPRO90
BGLY92
BSER93
BTYR95
BTHR96
BGLY139
BMET142
BTHR156
BASP157

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........YAVK
ChainResidueDetails
ALEU15-LYS38

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545
ChainResidueDetails
DTHR354
DTHR356
ETHR354
ETHR356

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545
ChainResidueDetails
DSER355
ESER355
BLEU15
BLYS38

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25636800
ChainResidueDetails
DSER358
ESER358

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499
ChainResidueDetails
DSER366
ESER366
ALYS401
BLYS30
BLYS401

219140

PDB entries from 2024-05-01

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