6O7Y

Trypanosoma cruzi EIF4E5 translation initiation factor in complex with cap-4

Summary for 6O7Y

• Entry DOI: 10.2210/pdb6o7y/pdb
• Related: 6O7Z 6O80
• Descriptor: Putative Eukaryotic translation initiation factor 4E type 5, 2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(S)-({(2R,3R,4R,5R)-3-{[(R)-{[(2R,3R,4R,5R)-3-{[(S)-{[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-{[(S)-hydroxy{[(2R,3R,4R,5R)-3-hydroxy-4-methoxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy}phosphoryl]oxy}-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-[6-(dimethylamino)-9H-purin-9-yl]-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium, SULFATE ION, ... (4 entities in total)
• Functional Keywords: rna binding protein, translation initiation factor, trypanosomatids, cap-4
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 1
• Total formula weight: 27286.95

Authors

Guimaraes, B.G.,Reolon, L.W. (deposition date: 2019-03-08, release date: 2019-05-01, Last modification date: 2024-03-13)

• Primary citation: Reolon, L.W.,Vichier-Guerre, S.,de Matos, B.M.,Dugue, L.,Assuncao, T.R.D.S.,Zanchin, N.I.T.,Pochet, S.,Guimaraes, B.G.; Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4.; Nucleic Acids Res., 47:5973-5987, 2019; PubMed: 31066441; DOI: 10.1093/nar/gkz339

Experimental method

X-RAY DIFFRACTION (2.2 Å)