6O5Y

Structure of Human Cytochrome P450 1A1 with 5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)

Summary for 6O5Y

• Entry DOI: 10.2210/pdb6o5y/pdb
• Descriptor: Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, 5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide, ... (5 entities in total)
• Functional Keywords: cyp1a1, p450, oxidoreductase, gdc-0339
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 226770.07

Authors

Bart, A.G.,Scott, E.E. (deposition date: 2019-03-04, release date: 2019-12-04, Last modification date: 2023-10-11)

• Primary citation: Bart, A.G.,Takahashi, R.H.,Wang, X.,Scott, E.E.; Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate.; Drug Metab.Dispos., 48:86-92, 2020; PubMed: 31757797; DOI: 10.1124/dmd.119.089607

Experimental method

X-RAY DIFFRACTION (3.17 Å)