6O5Y
Structure of Human Cytochrome P450 1A1 with 5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Cytochrome P450 1A1 | polymer | 491 | 55944.2 | 4 | UniProt (P04798) Pfam (PF00067) In PDB | Homo sapiens (Human) | CYPIA1,Cytochrome P450 form 6,Cytochrome P450-C,Cytochrome P450-P1 |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A | 5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide | non-polymer | 465.5 | 1 | Chemie (KUV) | |||
4 | B | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) | |||
5 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 35 - 512 (UniProt: P04798)
PDB | External Database | Details |
---|---|---|
Met 28 | - | initiating methionine |
Ala 29 | - | expression tag |
Lys 30 | - | expression tag |
Lys 31 | - | expression tag |
Thr 32 | - | expression tag |
Ser 33 | - | expression tag |
Ser 34 | - | expression tag |
His 513 | - | expression tag |
His 514 | - | expression tag |
His 515 | - | expression tag |
His 516 | - | expression tag |
His 517 | - | expression tag |
His 518 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 223776.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2993.4 | |
All* | Total formula weight | 226770.1 |