6O4U

Co-crystal structure of Mcl1 with inhibitor

Summary for 6O4U

• Entry DOI: 10.2210/pdb6o4u/pdb
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, (2~{S})-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-~{N}-(2-methylpropylsulfonyl)-2,3-dihydro-1,4-benzoxazine-6-carboxamide (3 entities in total)
• Functional Keywords: inhibitor, apoptosis, apoptosis-inhibitor complex, apoptosis/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 36609.38

Authors

Huang, X. (deposition date: 2019-03-01, release date: 2020-03-04, Last modification date: 2024-03-13)

• Primary citation: Huang, X.; Conformational Restriction Toward the Discovery of Macrocyclic MCL1 Inhibitors that Display Efficacy in Mouse Xenograft Models; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)