6O0R

Crystal structure of the TIR domain from human SARM1 in complex with glycerol

Summary for 6O0R

• Entry DOI: 10.2210/pdb6o0r/pdb
• Descriptor: Sterile alpha and TIR motif-containing protein 1, GLYCEROL (3 entities in total)
• Functional Keywords: axon degeneration, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 32851.59

Authors

Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Tiancong, Q.,Gilley, J.,Lai, J.,Gu, W.,Rank, M.,Deerain, N.,Casey, L.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B. (deposition date: 2019-02-17, release date: 2019-09-04, Last modification date: 2024-03-13)

• Primary citation: Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Qi, T.,Gilley, J.,Lai, J.S.,Rank, M.X.,Casey, L.W.,Gu, W.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B.; NAD+cleavage activity by animal and plant TIR domains in cell death pathways.; Science, 365:793-799, 2019; PubMed: 31439792; DOI: 10.1126/science.aax1911

Experimental method

X-RAY DIFFRACTION (1.8 Å)