6O0R
Crystal structure of the TIR domain from human SARM1 in complex with glycerol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003953 | molecular_function | NAD+ nucleosidase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| A | 0035591 | molecular_function | signaling adaptor activity |
| A | 0048678 | biological_process | response to axon injury |
| B | 0003953 | molecular_function | NAD+ nucleosidase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| B | 0035591 | molecular_function | signaling adaptor activity |
| B | 0048678 | biological_process | response to axon injury |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 801 |
| Chain | Residue |
| A | SER567 |
| A | TYR568 |
| A | ASP594 |
| A | LEU607 |
| A | GLU642 |
| A | HOH916 |
| A | HOH922 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 801 |
| Chain | Residue |
| B | TYR568 |
| B | ASP594 |
| B | LEU607 |
| B | GLU642 |
| B | HOH922 |
| B | HOH935 |
| B | PHE565 |
| B | SER567 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00204, ECO:0000305|PubMed:28334607, ECO:0000305|PubMed:31439792, ECO:0000305|PubMed:31439793 |
| Chain | Residue | Details |
| A | GLU642 | |
| B | GLU642 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:31439792 |
| Chain | Residue | Details |
| A | ARG569 | |
| A | GLU599 | |
| B | ARG569 | |
| B | GLU599 |
