6O0H
Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143
Summary for 6O0H
Entry DOI | 10.2210/pdb6o0h/pdb |
EMDB information | 0567 0568 |
Descriptor | ATP-citrate synthase, methyl 3-chloro-5-[(4,6-difluoro[1,1'-biphenyl]-3-yl)sulfamoyl]-4-hydroxybenzoate, ADENOSINE-5'-DIPHOSPHATE (3 entities in total) |
Functional Keywords | atp-citrate lyase, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 494672.59 |
Authors | |
Primary citation | Wei, J.,Leit, S.,Kuai, J.,Therrien, E.,Rafi, S.,Harwood Jr., H.J.,DeLaBarre, B.,Tong, L. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature, 568:566-570, 2019 Cited by PubMed: 30944472DOI: 10.1038/s41586-019-1094-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.67 Å) |
Structure validation
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