6NZD

Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)

6NZD の概要

• エントリーDOI: 10.2210/pdb6nzd/pdb
• EMDBエントリー: 0554 0556
• 分子名称: Ragulator complex protein LAMTOR1, GUANOSINE-5'-DIPHOSPHATE, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, ... (11 entities in total)
• 機能のキーワード: lysosome, mtorc1 regulation, amino acid sensing, gtpase, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 348515.78

構造登録者

Fromm, S.A.,Young, L.N.,Hurley, J.H. (登録日: 2019-02-13, 公開日: 2019-11-06, 最終更新日: 2019-12-18)

• 主引用文献: Lawrence, R.E.,Fromm, S.A.,Fu, Y.,Yokom, A.L.,Kim, D.J.,Thelen, A.M.,Young, L.N.,Lim, C.Y.,Samelson, A.J.,Hurley, J.H.,Zoncu, R.; Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.; Science, 366:971-977, 2019; PubMed: 31672913; DOI: 10.1126/science.aax0364

実験手法

ELECTRON MICROSCOPY (3.6 Å)