6NWL

Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with hydrocortisone and PGC1a coregulator fragment

6NWL の概要

• エントリーDOI: 10.2210/pdb6nwl/pdb
• 分子名称: glucocorticoid receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, ... (8 entities in total)
• 機能のキーワード: glucocorticoid receptor; agonist; coactivator, hormone
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31187.47

構造登録者

Liu, X.,Ortlund, E.A. (登録日: 2019-02-06, 公開日: 2019-10-23, 最終更新日: 2024-03-13)

• 主引用文献: Liu, X.,Wang, Y.,Ortlund, E.A.; First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids.; Mol.Pharmacol., 96:408-417, 2019; PubMed: 31391291; DOI: 10.1124/mol.119.116806

実験手法

X-RAY DIFFRACTION (1.595 Å)