6NVL

FGFR1 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide

6NVL の概要

• エントリーDOI: 10.2210/pdb6nvl/pdb
• 分子名称: Fibroblast growth factor receptor 1, SULFATE ION, N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide, ... (4 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 143115.41

構造登録者

Lin, X.,Smaill, J.B.,Squire, C.J. (登録日: 2019-02-05, 公開日: 2019-07-10, 最終更新日: 2023-10-11)

• 主引用文献: Lin, X.,Yosaatmadja, Y.,Kalyukina, M.,Middleditch, M.J.,Zhang, Z.,Lu, X.,Ding, K.,Patterson, A.V.,Smaill, J.B.,Squire, C.J.; Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.; Acs Med.Chem.Lett., 10:1180-1186, 2019; PubMed: 31413803; DOI: 10.1021/acsmedchemlett.9b00196

実験手法

X-RAY DIFFRACTION (2.7 Å)