6NUJ
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor BI-224436
Summary for 6NUJ
Entry DOI | 10.2210/pdb6nuj/pdb |
Descriptor | Integrase, (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid (3 entities in total) |
Functional Keywords | hiv, integrase, inhibitor, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 18886.19 |
Authors | Lindenberger, J.J.,Kvaratskhelia, M. (deposition date: 2019-02-01, release date: 2019-12-11, Last modification date: 2023-10-11) |
Primary citation | Koneru, P.C.,Francis, A.C.,Deng, N.,Rebensburg, S.V.,Hoyte, A.C.,Lindenberger, J.,Adu-Ampratwum, D.,Larue, R.C.,Wempe, M.F.,Engelman, A.N.,Lyumkis, D.,Fuchs, J.R.,Levy, R.M.,Melikyan, G.B.,Kvaratskhelia, M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife, 8:-, 2019 Cited by PubMed: 31120420DOI: 10.7554/eLife.46344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.10002700303 Å) |
Structure validation
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