6NTC

Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 1 of CRAF Kinase protein

6NTC の概要

• エントリーDOI: 10.2210/pdb6ntc/pdb
• 分子名称: GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• 機能のキーワード: affinity reagent, ras inhibitor, transferase-protein binding complex, transferase/protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29191.93

構造登録者

Maisonneuve, P.,Kurinov, I.,Wiechmann, S.,Ernst, A.,Sicheri, F. (登録日: 2019-01-28, 公開日: 2020-03-04, 最終更新日: 2023-10-11)

• 主引用文献: Wiechmann, S.,Maisonneuve, P.,Grebbin, B.M.,Hoffmeister, M.,Kaulich, M.,Clevers, H.,Rajalingam, K.,Kurinov, I.,Farin, H.F.,Sicheri, F.,Ernst, A.; Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.; J.Biol.Chem., 295:4526-4540, 2020; PubMed: 32086379; DOI: 10.1074/jbc.RA119.011025

実験手法

X-RAY DIFFRACTION (2.9 Å)