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6NT4

Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.

Summary for 6NT4
Entry DOI10.2210/pdb6nt4/pdb
Related6NT3
EMDB information0500 0501
DescriptorSodium channel protein PaFPC1,Sodium channel protein type 9 subunit alpha,Sodium channel protein PaFPC1, Alpha-mammal toxin AaH2, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywordssodium channel, scorpion toxin, electrical signaling, fast inactivation, membrane protein
Biological sourcePeriplaneta americana (American cockroach)
More
Total number of polymer chains3
Total formula weight201449.97
Authors
Clairfeuille, T.,Rohou, A.,Payandeh, J. (deposition date: 2019-01-28, release date: 2019-02-20, Last modification date: 2021-08-25)
Primary citationClairfeuille, T.,Cloake, A.,Infield, D.T.,Llongueras, J.P.,Arthur, C.P.,Li, Z.R.,Jian, Y.,Martin-Eauclaire, M.F.,Bougis, P.E.,Ciferri, C.,Ahern, C.A.,Bosmans, F.,Hackos, D.H.,Rohou, A.,Payandeh, J.
Structural basis of alpha-scorpion toxin action on Na v channels.
Science, 363:-, 2019
Cited by
PubMed: 30733386
DOI: 10.1126/science.aav8573
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.5 Å)
Structure validation

217705

건을2024-03-27부터공개중

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