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6NSP

TRK-A IN COMPLEX WITH LIGAND 9

Summary for 6NSP
Entry DOI10.2210/pdb6nsp/pdb
Related6NPT
DescriptorHigh affinity nerve growth factor receptor, N-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetamide (3 entities in total)
Functional Keywordstrk-a kinase domain high affinity nerve growth factor receptor inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34133.48
Authors
Subramanian, G.,Brown, D.G. (deposition date: 2019-01-25, release date: 2019-05-22, Last modification date: 2024-03-13)
Primary citationSubramanian, G.,Johnson, P.D.,Zachary, T.,Roush, N.,Zhu, Y.,Bowen, S.J.,Janssen, A.,Duclos, B.A.,Williams, T.,Javens, C.,Shalaly, N.D.,Molina, D.M.,Wittwer, A.J.,Hirsch, J.L.
Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.
Acs Chem.Biol., 14:1205-1216, 2019
Cited by
PubMed: 31059222
DOI: 10.1021/acschembio.9b00126
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.31 Å)
Structure validation

217705

数据于2024-03-27公开中

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