6NSP

TRK-A IN COMPLEX WITH LIGAND 9

6NSP の概要

• エントリーDOI: 10.2210/pdb6nsp/pdb
• 関連するPDBエントリー: 6NPT
• 分子名称: High affinity nerve growth factor receptor, N-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetamide (3 entities in total)
• 機能のキーワード: trk-a kinase domain high affinity nerve growth factor receptor inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34133.48

構造登録者

Subramanian, G.,Brown, D.G. (登録日: 2019-01-25, 公開日: 2019-05-22, 最終更新日: 2024-03-13)

• 主引用文献: Subramanian, G.,Johnson, P.D.,Zachary, T.,Roush, N.,Zhu, Y.,Bowen, S.J.,Janssen, A.,Duclos, B.A.,Williams, T.,Javens, C.,Shalaly, N.D.,Molina, D.M.,Wittwer, A.J.,Hirsch, J.L.; Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.; Acs Chem.Biol., 14:1205-1216, 2019; PubMed: 31059222; DOI: 10.1021/acschembio.9b00126

実験手法

X-RAY DIFFRACTION (2.31 Å)