6NR3
Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium
Summary for 6NR3
Entry DOI | 10.2210/pdb6nr3/pdb |
EMDB information | 0487 0488 0489 |
Descriptor | Transient receptor potential cation channel subfamily M member 8, Icilin, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, ... (4 entities in total) |
Functional Keywords | ion channel, trp channel, trpm channel, trpm8 channel, cold sensing, lipid sensing, menthol, icilin, ws-12, pi(4, 5)p2, cooling agent, membrane protein, calcium-permeable ion channel, transport protein |
Biological source | Ficedula albicollis (Collared flycatcher) More |
Total number of polymer chains | 4 |
Total formula weight | 525639.40 |
Authors | Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.-Y. (deposition date: 2019-01-22, release date: 2019-02-20, Last modification date: 2019-12-18) |
Primary citation | Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.Y. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363:-, 2019 Cited by PubMed: 30733385DOI: 10.1126/science.aav9334 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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