6NR3

Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily M member 8	polymer	1135	130011.4	4		Ficedula albicollis (Collared flycatcher)
2	E, H, K, N (A, B, C, D)	Icilin	non-polymer		311.3	4	Chemie (KX7)
3	F, I, L, O (A, B, C, D)	(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate	non-polymer		1047.1	4	Chemie (KXP)
4	G, J, M, P (A, B, C, D)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)

Sequence modifications

A, B, C, D: -42 - 52 (PDB: 6NR3)
A, B, C, D: 53 - 111 (PDB: 6NR3)
A, B, C, D: 116 - 1076 (PDB: 6NR3)
A, B, C, D: 1077 - 1133 (PDB: 6NR3)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	520045.6
Non-Polymers*	Number of molecules	12
	Total formula weight	5593.8
All*	Total formula weight	525639.4

*Water molecules are not included.