6NR3
Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Transient receptor potential cation channel subfamily M member 8 | polymer | 1135 | 130011.4 | 4 | Ficedula albicollis (Collared flycatcher) | ||
2 | A, B, C, D | Icilin | non-polymer | 311.3 | 4 | Chemie (KX7) | |||
3 | A, B, C, D | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 4 | Chemie (KXP) | |||
4 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 520045.6 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 5593.8 | |
All* | Total formula weight | 525639.4 |