6NR3

Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue KX7 A 1201

Chain	Residue
A	ASN741
A	ILE845
A	TYR1004
A	CA1203
A	VAL742
A	TYR745
A	LEU778
A	GLU782
A	ASP802
A	PHE838
A	ARG841
A	HIS844

---

site_id	AC2
Number of Residues	9
Details	binding site for residue KXP A 1202

Chain	Residue
A	SER679
A	ARG688
A	ASN692
A	PHE735
A	PHE738
A	SER849
A	ARG850
A	ARG997
D	LYS605

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 1203

Chain	Residue
A	GLU782
A	GLN785
A	ASN799
A	ASP802
A	KX71201

---

site_id	AC4
Number of Residues	12
Details	binding site for residue KX7 B 1201

Chain	Residue
B	ASN741
B	VAL742
B	TYR745
B	LEU778
B	GLU782
B	ASP802
B	PHE838
B	ARG841
B	HIS844
B	ILE845
B	TYR1004
B	CA1203

---

site_id	AC5
Number of Residues	9
Details	binding site for residue KXP B 1202

Chain	Residue
A	LYS605
B	SER679
B	ARG688
B	ASN692
B	PHE735
B	PHE738
B	SER849
B	ARG850
B	ARG997

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CA B 1203

Chain	Residue
B	GLU782
B	GLN785
B	ASN799
B	ASP802
B	KX71201

---

site_id	AC7
Number of Residues	12
Details	binding site for residue KX7 C 1201

Chain	Residue
C	ASN741
C	VAL742
C	TYR745
C	LEU778
C	GLU782
C	ASP802
C	PHE838
C	ARG841
C	HIS844
C	ILE845
C	TYR1004
C	CA1203

---

site_id	AC8
Number of Residues	9
Details	binding site for residue KXP C 1202

Chain	Residue
B	LYS605
C	SER679
C	ARG688
C	ASN692
C	PHE735
C	PHE738
C	SER849
C	ARG850
C	ARG997

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CA C 1203

Chain	Residue
C	GLU782
C	GLN785
C	ASN799
C	ASP802
C	KX71201

---

site_id	AD1
Number of Residues	12
Details	binding site for residue KX7 D 1201

Chain	Residue
D	ASN741
D	VAL742
D	TYR745
D	LEU778
D	GLU782
D	ASP802
D	PHE838
D	ARG841
D	HIS844
D	ILE845
D	TYR1004
D	CA1203

---

site_id	AD2
Number of Residues	9
Details	binding site for residue KXP D 1202

Chain	Residue
C	LYS605
D	SER679
D	ARG688
D	ASN692
D	PHE735
D	PHE738
D	SER849
D	ARG850
D	ARG997

---

site_id	AD3
Number of Residues	5
Details	binding site for residue CA D 1203

Chain	Residue
D	GLU782
D	GLN785
D	ASN799
D	ASP802
D	KX71201

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