6NR2
Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2
6NR2 の概要
エントリーDOI | 10.2210/pdb6nr2/pdb |
EMDBエントリー | 0487 0488 0489 |
分子名称 | Transient receptor potential cation channel subfamily M member 8, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide (3 entities in total) |
機能のキーワード | ion channel, trp channel, trpm channel, trpm8 channel, cold sensing, lipid sensing, menthol, icilin, ws-12, pi(4, 5)p2, cooling agent, membrane protein, calcium-permeable ion channel, transport protein |
由来する生物種 | Ficedula albicollis (Collared flycatcher) 詳細 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 525659.81 |
構造登録者 | Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.-Y. (登録日: 2019-01-22, 公開日: 2019-02-20, 最終更新日: 2019-12-18) |
主引用文献 | Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.Y. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363:-, 2019 Cited by PubMed: 30733385DOI: 10.1126/science.aav9334 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (4 Å) |
構造検証レポート
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