6NR2

Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2

6NR2 の概要

• エントリーDOI: 10.2210/pdb6nr2/pdb
• EMDBエントリー: 0487 0488 0489
• 分子名称: Transient receptor potential cation channel subfamily M member 8, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide (3 entities in total)
• 機能のキーワード: ion channel, trp channel, trpm channel, trpm8 channel, cold sensing, lipid sensing, menthol, icilin, ws-12, pi(4, 5)p2, cooling agent, membrane protein, calcium-permeable ion channel, transport protein
• 由来する生物種: Ficedula albicollis (Collared flycatcher); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 525659.81

構造登録者

Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.-Y. (登録日: 2019-01-22, 公開日: 2019-02-20, 最終更新日: 2019-12-18)

• 主引用文献: Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.Y.; Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.; Science, 363:-, 2019; PubMed: 30733385; DOI: 10.1126/science.aav9334

実験手法

ELECTRON MICROSCOPY (4 Å)