6NO7

Crystal Structure of the full-length wild-type PKA RIa Holoenzyme

Summary for 6NO7

• Entry DOI: 10.2210/pdb6no7/pdb
• Related: 2QCS
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: pka, ria holoenzyme, atp-dependent, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 335931.47

Authors

Lu, T.,Wu, J.,Taylor, S.S. (deposition date: 2019-01-15, release date: 2019-07-24, Last modification date: 2023-10-11)

• Primary citation: Lu, T.W.,Wu, J.,Aoto, P.C.,Weng, J.H.,Ahuja, L.G.,Sun, N.,Cheng, C.Y.,Zhang, P.,Taylor, S.S.; Two PKA RI alpha holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP.; Proc.Natl.Acad.Sci.USA, 116:16347-16356, 2019; PubMed: 31363049; DOI: 10.1073/pnas.1906036116

Experimental method

X-RAY DIFFRACTION (3.55 Å)