6NNA
Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and Compound 22
Summary for 6NNA
Entry DOI | 10.2210/pdb6nna/pdb |
Descriptor | Fatty acid synthase,Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {4-[4-(1,3-benzoxazol-2-yl)benzene-1-carbonyl]piperazin-1-yl}(1-hydroxycyclopropyl)methanone, ... (5 entities in total) |
Functional Keywords | fatty acid synthase, human fas, keto-reductase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 147010.77 |
Authors | Toms, A.V.,Martin, M.W. (deposition date: 2019-01-14, release date: 2019-02-20, Last modification date: 2023-10-11) |
Primary citation | Martin, M.W.,Lancia Jr., D.R.,Li, H.,Schiller, S.E.R.,Toms, A.V.,Wang, Z.,Bair, K.W.,Castro, J.,Fessler, S.,Gotur, D.,Hubbs, S.E.,Kauffman, G.S.,Kershaw, M.,Luke, G.P.,McKinnon, C.,Yao, L.,Lu, W.,Millan, D.S. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg. Med. Chem. Lett., 29:1001-1006, 2019 Cited by PubMed: 30803804DOI: 10.1016/j.bmcl.2019.02.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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