6NN7

The structure of human liver pyruvate kinase, hLPYK-GGG

Summary for 6NN7

DescriptorPyruvate kinase PKLR, 1,2-ETHANEDIOL, GLYCEROL, ... (5 entities in total)
Functional Keywordspyruvate kinase, allosteric, glycolysis, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight470218.83
Authors
McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Fenton, A.W.,Lamb, A.L. (deposition date: 2019-01-14, release date: 2019-06-19)
Primary citation
McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Chilton, A.,Fenton, A.W.,Lamb, A.L.
Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond
Acta Crystallogr.,Sect.F, 75:461-469, 2019
DOI: 10.1107/s2053230x19007209
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.32 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2526 0.4% 1.7% 7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution