6NN4
The structure of human liver pyruvate kinase, hLPYK-D499N, in complex with Fru-1,6-BP
Summary for 6NN4
Entry DOI | 10.2210/pdb6nn4/pdb |
Descriptor | Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | pyruvate kinase, allosteric, glycolysis, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 236719.81 |
Authors | McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Fenton, A.W.,Lamb, A.L. (deposition date: 2019-01-14, release date: 2019-06-19, Last modification date: 2023-10-11) |
Primary citation | McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Chilton, A.,Fenton, A.W.,Lamb, A.L. Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond. Acta Crystallogr.,Sect.F, 75:461-469, 2019 Cited by PubMed: 31204694DOI: 10.1107/S2053230X19007209 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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