6NMQ

Hypoxia-Inducible Factor (HIF) Prolyl Hydroxylase 2 (PHD2) in Complex with the Carboxamide Analog JNJ43058171

Summary for 6NMQ

• Entry DOI: 10.2210/pdb6nmq/pdb
• Related: 3OUJ
• Descriptor: Egl nine homolog 1, FE (II) ION, N-(4-oxo-1,4-dihydrocinnoline-3-carbonyl)glycine, ... (4 entities in total)
• Functional Keywords: phd2, hypoxia-inducible factor prolyl hydroxylase, iron-containing enzyme, cinnoline, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 24232.28

Authors

Bembenek, S.D.,Mirzadegan, T. (deposition date: 2019-01-11, release date: 2019-04-24, Last modification date: 2024-03-13)

• Primary citation: Bembenek, S.D.,Venkatesan, H.,Peltier, H.M.,Rosen, M.D.,Barrett, T.D.,Kanelakis, K.C.,Palomino, H.L.,Brondstetter, T.I.,Mirzadegan, T.,Rabinowitz, M.H.; Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.; Acs Omega, 4:6703-6708, 2019; PubMed: 31179408; DOI: 10.1021/acsomega.9b00199

Experimental method

X-RAY DIFFRACTION (1.58 Å)