6NMQ
Hypoxia-Inducible Factor (HIF) Prolyl Hydroxylase 2 (PHD2) in Complex with the Carboxamide Analog JNJ43058171
Summary for 6NMQ
Entry DOI | 10.2210/pdb6nmq/pdb |
Related | 3OUJ |
Descriptor | Egl nine homolog 1, FE (II) ION, N-(4-oxo-1,4-dihydrocinnoline-3-carbonyl)glycine, ... (4 entities in total) |
Functional Keywords | phd2, hypoxia-inducible factor prolyl hydroxylase, iron-containing enzyme, cinnoline, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 24232.28 |
Authors | Bembenek, S.D.,Mirzadegan, T. (deposition date: 2019-01-11, release date: 2019-04-24, Last modification date: 2024-03-13) |
Primary citation | Bembenek, S.D.,Venkatesan, H.,Peltier, H.M.,Rosen, M.D.,Barrett, T.D.,Kanelakis, K.C.,Palomino, H.L.,Brondstetter, T.I.,Mirzadegan, T.,Rabinowitz, M.H. Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2. Acs Omega, 4:6703-6708, 2019 Cited by PubMed: 31179408DOI: 10.1021/acsomega.9b00199 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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