6NMB

Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator

6NMB の概要

• エントリーDOI: 10.2210/pdb6nmb/pdb
• 分子名称: Urokinase-type plasminogen activator, NITRATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, ... (4 entities in total)
• 機能のキーワード: serine protease, fibrinolysis, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128910.76

構造登録者

Law, R.H.P.,Wu, G. (登録日: 2019-01-10, 公開日: 2019-03-06, 最終更新日: 2024-10-30)

主引用文献

Wu, G.,Mazzitelli, B.A.,Quek, A.J.,Veldman, M.J.,Conroy, P.J.,Caradoc-Davies, T.T.,Ooms, L.M.,Tuck, K.L.,Schoenecker, J.G.,Whisstock, J.C.,Law, R.H.P.
Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Blood Adv, 3:729-733, 2019

PubMed Abstract: TXA is an active-site inhibitor of uPA. TXA attenuates MDA-MB-231 BAG cell migration and inhibits endogenous uPA activity.

PubMed: 30814058
DOI: 10.1182/bloodadvances.2018025429

実験手法

X-RAY DIFFRACTION (2.3 Å)