6NIY

A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex

6NIY の概要

• エントリーDOI: 10.2210/pdb6niy/pdb
• EMDBエントリー: 8623 9382
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Nanobody35, Calcitonin receptor, ... (6 entities in total)
• 機能のキーワード: gpcr, transmembrane, receptor, calcitonin, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 164970.54

構造登録者

dal Maso, E.,Glukhova, A.,Zhu, Y.,Garcia-Nafria, J.,Tate, C.G.,Atanasio, S.,Reynolds, C.A.,Ramirez-Aportela, E.,Carazo, J.-M.,Hick, C.A.,Furness, S.G.B.,Hay, D.L.,Liang, Y.-L.,Miller, L.J.,Christopoulos, A.,Wang, M.-W.,Wootten, D.,Sexton, P.M. (登録日: 2019-01-02, 公開日: 2019-01-23, 最終更新日: 2020-04-08)

• 主引用文献: Dal Maso, E.,Glukhova, A.,Zhu, Y.,Garcia-Nafria, J.,Tate, C.G.,Atanasio, S.,Reynolds, C.A.,Ramirez-Aportela, E.,Carazo, J.M.,Hick, C.A.,Furness, S.G.B.,Hay, D.L.,Liang, Y.L.,Miller, L.J.,Christopoulos, A.,Wang, M.W.,Wootten, D.,Sexton, P.M.; The Molecular Control of Calcitonin Receptor Signaling.; Acs Pharmacol Transl Sci, 2:31-51, 2019; PubMed: 32219215; DOI: 10.1021/acsptsci.8b00056

実験手法

ELECTRON MICROSCOPY (3.34 Å)