6NHA
Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody
Summary for 6NHA
Entry DOI | 10.2210/pdb6nha/pdb |
Descriptor | IgG receptor FcRn large subunit p51, Beta-2-microglobulin, SYNT001-Fab light chain, ... (6 entities in total) |
Functional Keywords | fcrn, b2m, circulating igg and igg immune complex, synt001, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 90404.19 |
Authors | Blumberg, R.S.,Cheung, J.,Mahmood, A.,Gandhi, A.K. (deposition date: 2018-12-21, release date: 2019-12-25, Last modification date: 2023-10-11) |
Primary citation | Blumberg, L.J.,Humphries, J.E.,Jones, S.D.,Pearce, L.B.,Holgate, R.,Hearn, A.,Cheung, J.,Mahmood, A.,Del Tito, B.,Graydon, J.S.,Stolz, L.E.,Bitonti, A.,Purohit, S.,de Graaf, D.,Kacena, K.,Andersen, J.T.,Christianson, G.J.,Roopenian, D.C.,Hubbard, J.J.,Gandhi, A.K.,Lasseter, K.,Pyzik, M.,Blumberg, R.S. Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. Sci Adv, 5:eaax9586-eaax9586, 2019 Cited by PubMed: 31897428DOI: 10.1126/sciadv.aax9586 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.381 Å) |
Structure validation
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